ALK inhibitor 2 ( ALK inhibitor 2; MDK-8384; MDK 8384 )

Catalog No. M19086 CAS No. 761438-38-4

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Product Name

ALK inhibitor 2
Note

Research use only, not for human use.
Brief Description

ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
Description

MDK-8384, also known as ALK inhibitor 2, is a potent and selective ALK inhibitor. MDK-8384 has CAS#761438-38-4. MDK-8384 was reported in J Med Chem. 2013;56(14):5675-90.
Synonyms

ALK inhibitor 2; MDK-8384; MDK 8384
Pathway

Others
Target

Other Targets
Recptor

ALK
Research Area

Cancer
Indication

——

CAS Number

761438-38-4
Formula Weight

518.03
Molecular Formula

C23H28ClN7O3S
Purity

98%
Solubility

DMSO : 50 mg/mL 96.52 mM;H2O : < 0.1 mg/mL
SMILES

c1cc(c(cc1)Nc1c(cnc(n1)Nc1c(cc(cc1)N1CCN(CC1)C)OC)Cl)S(=O)(=O)NC
Chemical Name

2-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]-N-methylbenzenesulfonamide

1. A Dose Finding Study With Oral LDK378 in Patients With Tumors Characterized by Genetic Abnormalities in Anaplastic Lymphoma Kinase (ALK).

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